If you prioritize open-source solutions and want a tool that can be self-hosted, go for Penpot. It's an excellent choice for privacy-conscious teams and advocates of open-source software. You'll benefit from real-time collaboration and a design environment that’s friendly to both designers and developers. However, be aware that it has a smaller ecosystem than Figma and may not deliver the same level of polish.
On the other hand, if you’re looking to quickly design and publish websites without any coding, Framer is the better option. Its freemium model allows you to start for free, and its strong animations and CMS capabilities make it ideal for marketing sites and portfolios. However, if you're planning a complex web application requiring custom domains or in-depth coding, Framer may not be the best fit, as it offers less control over code and hosting.