If you're an open-source advocate or part of a privacy-conscious team, choose Penpot. Its genuinely open-source nature, real-time collaboration, and designer-developer friendliness are great assets. However, be aware that it comes with a smaller ecosystem than Figma and might not provide the polished experience you're used to with more mature tools.
On the other hand, if you're looking to design and publish a real website without coding, Framer is your best bet. Its strong animations and built-in CMS make it perfect for creating marketing sites or portfolios quickly. Just note that for custom domains and scalability, you'll need to move to a paid plan, and it may lack the flexibility for more complex web applications.